Using the IV Bag will instantly kill The Lost even with the Holy Mantle.Holy Mantle breaking only grants one second of invincibility frames, regardless of the damage source.After reaching Womb, The Lost becomes slightly easier to play, because the invincibility frames from Holy Mantle scale with the damage that would have been taken.Leaving the room will regenerate the shield. Upon using the D4, the holy mantle effect will be temporarily lost.Being innate, this holy mantle effect is not shown in the HUD nor in the pause menu.Holy Mantle is intrinsic, but picking up another one does not double the effect.The Lost starts with Eternal D6, even before it's unlocked.The Lost's Holy Mantle effect is intrinsic to the character once unlocked, and it can't be rerolled.Using the D4 at all is not recommended as it will remove the Holy Mantle, making The Lost die in one hit.If The Lost's Holy Mantle effect is lost while within a Curse room, closing the game, starting it up and then continuing the run will restore the Holy Mantle's charge, allowing The Lost to leave the room unharmed.Since the Lost's Holy Mantle isn't intrinsic, the Victory Lap Lost will always die from one hit unless the player has explicitly found the Holy Mantle.Isaac will be replaced by The Lost upon starting a third victory lap however, Victory Laps do not allow the unlocking of achievements.Credit Card or Diplopia are even more valuable, as Devil Deals are now choices.Thus, a Credit Card is still recommended, or getting Chaos to acquire angel room items (except broken key pieces). Devil deals, while free, still count as making a deal with the devil and will prevent angel rooms from opening.Resurrection items like Dead Cat are very valuable to The Lost because they are the only health ups you can get.The Lost can take every devil deal in the first room of the Dark Room if the red chests are opened one by one.Unlike other choices, devil deals cloned with items like Diplopia or Crooked Penny will not be a choice.Taking one will despawn all other deals in the room. Devil deals and Black Market items are presented as choices.The Lost can take devil deals and Black Market items for free. The Lost can activate the button in Greed mode without taking damage, in exchange of one coin less of the next wave's reward. The Lost starts with flight, spectral tears, Eternal D6, and the effect of Holy Mantle (after donating 879 coins to the Greed Machine) This form of Holy Mantle is inherent to the character rather than being a starting item, and as such will be present when switching to The Lost in the middle of the run through the use of Clicker, will not be present when switching away, and cannot be removed by any means.ДЈDS The Lost also starts with D4 (if unlocked).The Lost starts with flight, spectral tears, D4 (if unlocked) and Holy Mantle (after donating 879 coins to the Greed Machine).

Therefore, it will die from any damage taken. The Lost starts with no health and cannot gain health by any means. Die in a Sacrifice Room while holding Missing Poster

Binding of the lost